In this study, the data from the mouse model with FHF induced by LPS/D-GalN demonstrated that liver injury was associated with elevated serum C3a levels, extensive hepatic deposition of C3 and increased hepatic expression of C3aR mRNA and C5aR mRNA, along with elevated serum levels of proinflammatory cytokines and ALT. Here, C3 is linked to TNF receptor 1-associated periodic fever syndrome.