While some studies report a positive association between high SPARC and more aggressive tumors [19], [20], several studies, including our own, support the view that it functions in part as a tumor suppressor in neuroblastomas, leukemias, colorectal, ovarian, pancreatic, lung, and breast cancers [3], [4], [6], [7], [21], [22]. This evidence concerns the gene SPARC and neoplasm.