CD8A and X-linked lymphoproliferative disease: First, although EBV can presumably be presented by numerous non-B-cell types of APCs (e.g., tonsillar epitheilium, cross-primed DCs) [63],[64], and this may contribute to the initial generation of detectable EBV-specific CD8+ T cells in XLP patients [19],[59], the predominant APC involved in maintaining a robust anti-EBV CD8+ T cell–mediated immune response appears to be B cells.