The three SNPs associated with IL-18 levels, − 105/rs5744292, + 1467/rs5744256 and + 183/rs360717, were also not associated with T1D (p ≥ 0.03; Table 3), nor were the IL18 haplotypes defined by the two SNPs − 105/rs5744292 and + 183/rs360717 (p = 0.82; Table 4), which have been shown to be associated with decreased IL-18 levels 16, 25. The gene discussed is IL18; the disease is type 1 diabetes mellitus.