However, these T1D-associated SNPs are not in linkage disequilibrium with the asthma-associated SNP rs2284033 (D′ < 0.2) and, therefore, they probably have different effects on the expression of IL2RB, the strongest candidate gene in the region given the importance of the IL-2 pathway in T1D 1. The gene discussed is IL2RB; the disease is type 1 diabetes mellitus.