POMC and neoplasm: TARTs are ACTH-dependent and may develop during periods of sustained elevation of plasma ACTH levels or regress when glucocorticoid therapy is instituted or intensified.4,5,27-34 However, in several studies, no correlation was found between intensive glucocorticoid therapy control and tumor growth.4,5,8,9,35-37 Therefore, other factors may interfere.