The TMPRSS4 was highly expressed in 14 cell lines: Eight of them were derived from AC (H441, H2087, CALU3, H1648, HCC827, H358, PC14 and H322), one from SCC (H2170), three from SCLC (H187, H209 and H510), one from large cell carcinoma (97TM1) and one from carcinoid (H727). The gene discussed is TMPRSS4; the disease is large cell carcinoma.