Samples that stained positive for ER, PR and HER2 resulted in DASL mRNA average transcript fold changes in ESR1, PGR and ERBB2 (95% CI) of 4.46 (2.01–6.90), 3.41 (1.24–5.58) and 3.59 (1.40–5.77) greater than their respective IHC-negative tumours. The gene discussed is ERBB2; the disease is neoplasm.