ZMPSTE24 and Hutchinson-Gilford progeria syndrome: The metalloproteinase, Zmpste24, is responsible for the sequential proteolytic cleavage of prelamin A into functional and mature lamin A. The point mutation identified from HGPS patients results in the activation of an aberrant cryptic splice site causing the deletion of a 50 amino acid region from the C-terminal end of prelamin A [35].