GPT and hepatocellular carcinoma: To examine if the levels of miR-21 in sera from patients with CHC as well as CHC plus HCC reflects necroinflammatory activity in the liver rather than HCC, we correlated the dCT values of serum miR-21 with ALT, aspartate aminotransferase (AST) as well as with the histologic activity index (HAI) score in the liver.