Fourth, immunohistochemical analysis also showed that AKBA downregulated the expression of proinflammatory biomarker COX-2, suppressed the expression of invasion biomarker MMP-9 and CXCR4, and inhibited the angiogenic biomarker VEGF in the PaCa tissues. This evidence concerns the gene VEGFA and permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.