This observation of MUC16 being significantly upregulated in PC is coherent with the expression of other membrane bound mucins MUC4 and MUC1 which are also aberrantly expressed in PC and have been identified as potential diagnostic markers for this malignancy [24], [28]–[31] We also observed that MUC16 expression increased progressively with loss of differentiation of the PC tumor. This evidence concerns the gene MUC4 and pachyonychia congenita.