While previous studies [17], [18] have demonstrated that female gender combined with high CD4+ T cell count significantly increased the incidence of nevirapine-induced liver toxicity, our data found a non-significant, modest increase of liver toxicity in female patients with high baseline CD4+ count (>250/mm3) (29% vs. 16%, p = 0.184). This evidence concerns the gene CD4 and hepatotoxicity.