MYH14 and carcinoma: Although we did not carry out experiments to confirm whether myosin and actin distributions in the lenses were altered with ML-7, other investigators have shown that ML-7 reduces the stiffness of nonmuscle cells such as fibroblasts [13], and induces loss of, or prevents formation of actin stress fiber bundles in human carcinoma [14], fibroblast [14-16] and endothelial cells [17,18].