HTR4 and hereditary sensory and autonomic neuropathy: Prucalopride is a potent, highly-selective 5HT4 agonist with no 5HT3 antagonism and no anticholinergic activity.17 It enhances peristalsis and accelerates colonic transit.10, 18–20 Prucalopride also accelerates small bowel transit in animals and humans.10, 11, 18 As such, prucalopride is a potentially beneficial agent in patients with CIP, where small and large bowel motility are perturbed.