What remains interesting is that AEG-1 mediated-activation of RISCs appears to be a general observation for all RISCs in cells with high AEG-1 expression, and yet it is unclear whether the net oncogenic effects of microRNAs documented in cancer cells are due to a selective interaction between AEG-1 and onco-miR-containing RISCs. The gene discussed is MTDH; the disease is cancer.