Chronic consumption may also influence postprandial response to these fats as a high monounsaturated fat diet for 12 weeks prior to an acute monounsaturated fat challenge had a favorable effect on postprandial ICAM-1 levels compared to 12 weeks of a higher saturated fat diet prior to a high saturated fat meal in metabolic syndrome patients [45]. The gene discussed is ICAM1; the disease is metabolic syndrome.