IL2 and vasculitis: These toxic changes were significantly expressed in the immunologic parameters as neutrophils, lymphocytes, anti-SRBC, and IL-2 (especially in alprazolam-treated stressed rats), supported by the histopathological findings as depletion of lymphocytes from the spleens, lymph nodes and thymuses, congestion, edema, hemosiderosis, inflammatory cells infiltration, large vessels eosinophilic infiltration, vasculitis, plaques and degeneration.