The minor allele of FGFR2 SNP rs2981582 was associated with a significantly higher risk for PR-positive breast cancer for BRCA1 mutation carriers (per-allele HR for PR-positive = 1.29, 95% CI: 1.10 to 1.51, HR for PR-negative = 0.93, 95% CI: 0.87 to 1.00, P-heterogeneity = 7 × 10-4). This evidence concerns the gene BRCA1 and breast cancer.