Previous studies demonstrated that SNPs, which are associated with ER-positive breast cancer in the general population, tend to be associated with the breast cancer risk for BRCA2 mutation carriers and SNPs, which are associated with ER-negative breast cancer in the general population, tend to be associated with the breast cancer risk for BRCA1 mutation carriers [27,31,44-46]. This evidence concerns the gene BRCA1 and breast carcinoma.