ESR1 and breast cancer: The 6q25.1 SNP rs2046210 near ESR1 was associated with the risk for both ER-negative (per-allele HR = 1.19, 95% CI: 1.11 to 1.27, P-trend = 2.4 × 10-7) and ER-positive (per-allele HR = 1.14, 95% CI: 1.01 to 1.30, P-trend = 0.043) breast cancer.