The χ2 test demonstrated that liver metastasis is associated with age (P < 0.001), tumor size (P = 0.001), type of tumor (P = 0.002), tumor cell differentiation (P < 0.001), tumor invasion depth (P = 0.002), lymph node metastasis (P = 0.001) and nuclear beta-catenin overexpression in metastatic SLN(s) (P < 0.001) (Table 3). The gene discussed is CTNNB1; the disease is neoplasm.