These factors are age (P = 0.004), tumor size (P = 0.002), tumor invasion depth (P < 0.001), tumor cell differentiation (P = 0.023), lymph node metastasis (P = 0.002) and nuclear beta-catenin overexpression in metastatic SLN(s) (P < 0.001). The gene discussed is CTNNB1; the disease is metastatic malignant neoplasm in the lymph nodes.