In addition, two prominent tumor suppressor loci were identified as major nodes in the established tumors, namely CDKN2A and TP53. Notably, the CDKN2A locus is deleted in up to 90% of cases of T-cell leukemia [65], while this locus is silenced through methylation in other forms of leukemia. The gene discussed is CDKN2A; the disease is leukemia.