Many of these genes function in inflammation (CXCR3, EOMES, IL18R1, GZMM, IL2rb) [66], metastases (CXCR3, BUB1) [66-68], poor outcome cancers (EOMES, BUB1) [67,68], or stem cells (EOMES, BUB1) [67-71]. Here, IL18R1 is linked to cancer.