Comparing such "local" expression profile (paired normal and cancer conditions) with the "global" expression profile (across various conditions) identified that of these 17 genes, 12 genes (ESR1, SPDEF, IRX5, ERBB3, ERBB2, CRABP2, RAB25, FXYD3, TACSTD2, DSP, AGR2, CDH1) show bimodality in both datasets (Figure 5 shows the flow chart of the procedure). This evidence concerns the gene SPDEF and cancer.