Because of the pivotal role caused by DUX4 expression in the FSHD pathology [8], [9], [17], [18] we wished to suppress its expression using small double-stranded RNAs (siRNAs) or antisense oligonucleotides (AOs) in the aim to develop therapeutic strategies for FSHD. This evidence concerns the gene DUX4 and facioscapulohumeral muscular dystrophy.