FGFR2 and Apert syndrome: To test whether the two Apert syndrome Fgfr2 mutations alter the covariation structure of the skulls of mutant mice relative to their non-mutant littermates, and whether the effects of these mutations on MI patterns are similar, we use geometric morphometric analysis of 3D landmark data collected from the newborn (P0) skulls of Fgfr2+/S252W and Fgfr2+/P253R Apert syndrome mouse models [6], [7].