Misregulation can lead to severe dysmorphogenesis and disease, as in the case of the FGFR-related craniosynostosis syndromes (e.g. Apert, Crouzon, Muenke, and Pfeiffer syndromes), which have a prevalence of 6–7 per 100,000 live births and are caused by mutations on FGFR1, 2 and 3. Here, FGFR1 is linked to craniosynostosis.