In this study, the ischemic model induced by middle cerebral artery occlusion also resulted in a mild transient retinal ischemia with neuronal cell damage in mice with F1 hybrid background, as suggested by increased GFAP immunoreactivity in the Müller cell processes and astrocytes, and the presence of pyknotic nuclei in the cells in GCL in the NTg ipsilateral retinae. This evidence concerns the gene GFAP and retinal ischemia.