ERBB2 and ductal breast carcinoma in situ: The significant association of grade 3 cancers with DCIS was documented by Chagpar et al (2009) and evidence has been presented that when invasive malignancies present as calcifications, the invasive cancers are often HER2 positive, a feature that has been associated with poorer prognosis in prior studies (Gajdos et al, 2002; Seo et al, 2006).