In addition to the Tcregs, the CD8+ T cells contained a population of Tc17 cells, and we found that the percentage of Tc17 cells in PBMCs from NPC patients (mean = 0.29 ± 0.31%, n = 21) was significantly lower than that in PBMCs from healthy donors (mean = 1.04 ± 0.72%, n = 21) or TILs from the paired NPC patients (mean = 0.96 ± 1.12%, n = 21) (P < 0.005, Figure 2C, D). The gene discussed is CD8A; the disease is nasopharyngeal carcinoma.