To investigate the existence of EBV-antigen-specific Tcregs in NPC, we used tetramer staining to determine the frequency of CD8+ T cells and Tcregs from PBMCs and TILs of HLA-A2-positive NPC patients that were specific for the HLA-A2-restricted EBV epitopes LMP1 (YLQ) and LMP2 (LLW, GLG). This evidence concerns the gene PSMB9 and nasopharyngeal carcinoma.