TNF and neoplasm: Moreover, the Tcregs from the tumor-infiltrating lymphocytes (TILs) secreted high levels of IL-10 and IFNγ but low levels of IL-2, IL-4, TNFα, and IL-17, resulting in a Tr1-like cytokine profile; Tcregs from PBMCs, in contrast, secreted high levels of IL-10 and low levels of transforming growth factor β (TGFβ), IL-2, IFNγ, TNFα, and IL-17.