GNRH1 and breast cancer: Endocrine suppression using gonadotropin releasing hormone (GnRH) analogs such as goserelin (a super-agonist) is commonly used for the treatment of pre-menopausal estrogen-responsive breast cancer because it lowers plasma levels of estrogen by inhibiting secretion of luteinizing hormone and follicle stimulating hormone from the pituitary gland [1,2] and thereby slows estrogen-driven tumor growth.