In contrast, transient alterations in the levels of p-ERK1/2 do occur in cells which are growth-inhibited by GnRH receptor activation, even in the presence of growth factors (HEK293[SCL60] B35-2 neuroblastoma and prostate WPE-1-NB26-3) [8,9]. The gene discussed is GNRHR; the disease is neuroblastoma.