INS and type 2 diabetes mellitus: Similar findings have been noted in preliminary reports of clinical experience with liraglutide plus insulin [49–51], and a preliminary report of a randomized study showed that the addition of insulin detemir to metformin and liraglutide (1.8 mg/day) in patients with T2DM generated a substantial reduction in HbA1c, with a small reduction in bodyweight and low rates of hypoglycaemia [52].