The participants with diastolic dysfunction had on average a higher body mass index (28.34 ± 4.50 vs. 27.01 ± 4.55 kg/m2; p = 0.014), more frequent a history of arterial hypertension (82 vs. 63.9%; p = 0.001) and of hospitalization for congestive heart failure (13.1 vs. 5.3%; p = 0.033), poorer quality of life (9.77 ± 10.52 vs 6.84 ± 8.11 score; p = 0.008), and higher BNP blood levels (86.18 ± 178.92 vs. 51.79 ± 50.4 pg/mL; p = 0.018) as compared to those participants without signs of diastolic dysfunction. This evidence concerns the gene NPPB and congestive heart failure.