BACE1 and Alzheimer disease: In addition, it has been reported that IFN-γ alone stimulated BACE1 expression and β-secretase cleavage in human astrocytoma cells and astrocytes derived from Tg2576 transgenic mice that overexpress human APP with the Swedish familial AD mutation (APPsw), but its effect on Aβ production was not investigated [37,38].