Moreover, they raised the possibility of a “Janus-like” effect where they reported in a retrospective analysis a significant reduction of the luminal diameters and epicardial conductance of the IR artery, as assessed from the pressure-derived FFR [13] mainly in early compared to late IC CD133+ cells administration [17] which seems to be consistent with a higher risk for atherosclerosis progression. This evidence concerns the gene PROM1 and atherosclerosis.