Uzgare et al. [41], using a transgenic mouse model for prostate cancer, described that p-p38 is overexpressed in prostatic intraepithelial neoplasia (PIN), well-differentiated and moderately differentiated cancers while was reduced or absent in late-stage adenocarcinomas and metastatic deposits. This evidence concerns the gene MAPK1 and prostate intraepithelial neoplasia.