Reduced levels of proinflammatory cytokines/chemokines, proapoptotic gene expression, and amounts of ROS/RNS from islets were observed, with islets more resistant to TNFα- and IFNγ-induced apoptosis, providing valuable insight into the development of better strategies for clinical islet transplantation in patients with T1D. The gene discussed is TNF; the disease is type 1 diabetes mellitus.