Intraductal administration of JNK inhibitor significantly suppressed mRNA expression levels of IL-1β, IFN-γ, TNF-α, IL-6, IL-8, and MCP-1 in vivo and also decreased the concentration of IL-1β and IL-8 in culture supernatant in vitro possibly representing an alternative target for suppression of porcine islet inflammation. This evidence concerns the gene CXCL8 and inflammation.