Western blot analysis revealed that the changes of survivin, Bcl-XL, Bcl-2, and Mcl-1 protein in C6 glioma cells treated with 10 μmol/L of LY294002, or/and 5 μmol/L of tamoxifen for 24 h were similar as the changes of mRNA (Fig. 10B). The gene discussed is BCL2; the disease is central nervous system cancer.