PLA2G6 and neurodegeneration with brain iron accumulation 2A: Marked cerebellar atrophy is the most characteristic MRI feature of INAD patients [11], [12], [13], [14] and observed in almost all INAD patients with mutations in PLA2G6[3], [4], [5], [6], [15], [16], [17], [18], suggesting a neuropathologic role of dysfunctional iPLA2β in the cerebellar atrophy in the INAD patients.