An important finding in our study is that the cerebellar atrophy observed in iPLA2β-/- mice is associated with reactive astrogliosis, overactivation of microglial cells, and pronounced upregulation of pro-inflammatory cytokines including IL-1β and TNFα — all features of neuroinflammation associated with a vast array of CNS pathologies [26]. This evidence concerns the gene TNF and Atrophy.