Previous studies focusing on gene signatures indicative of TB disease versus latent infection [3], [5], [6], [9] have revealed several clusters of differentially regulated genes including genes involved in type I and II interferon (IFN) signaling, cell type-specific signatures such as increased NK cell and neutrophil activity [5], [6], involvement of RAB33A and SOCS3 in T cells [9], [10], and markers of apoptosis [6]. This evidence concerns the gene IFNA1 and tuberculosis.