Five SNPs, rs10830963 in the MTNR1B locus, rs2943641 in the IRS1 locus, rs972283 in the KLF14 locus, rs231362 in the KCNQ1 locus, and rs11634397 in the ZFAND6 locus, had nominal association with type 2 diabetes in the present Japanese samples (P<0.05, Table 2 and Table S2), but these associations were not remained significant after Bonferroni's correction. Here, IRS1 is linked to type 2 diabetes mellitus.