Also, up-regulation of six cytokines (CXCL1- 3, IL-8, MIP-3a, Angiopoetin like4) by a melanoma cell line (NA8) cultured on poly-2-hydroxyethyl methacrylate (polyHEMA) plates was reported by Ghosh at al. [18]. This evidence concerns the gene CXCL8 and melanoma.