For example, NLRP3 is activated by uric acid crystals, cholesterol crystals, amyloid crystals, as well as high glucose levels which render NLRP3 activation as a crucial element of a number of important inflammatory diseases such as gout, atherosclerosis, amyloidosis and diabetes [13], [14], [15], [16]. The gene discussed is NLRP3; the disease is atherosclerosis.