After adjusting for multiple comparisons, the results of the ANOVA test showed a significant genotype effect for the following smoking-related phenotypes (Table 3, all P<0.017) (i) mean CPD and CYP2A13*3; (ii) PYS and CYP2A6*2, CYP2A6*1x2, CYP2A13*7, CYP2B6*4 and DRD2-ANKK1 2137G>A (Taq1A); (iii) nicotine dependence (FTND) and CYP2A6*9. The gene discussed is ANKK1; the disease is nicotine dependence.