Recently, a genome-wide association study (GWAS) revealed that several highly correlated common single nucleotide polymorphisms (SNPs), in a linkage disequilibrium (LD) block encompassing the IL-28B genes on chromosome 19q13, are implicated in the response of chronic hepatitis C (CHC) patients to pegylated IFN-alpha (PEG-IFNα) and ribavirin (RBV) [12], [13], [14]. This evidence concerns the gene IFNL3 and cryohydrocytosis.