FGF21 and Insulin resistance: Also, elevated fasting plasma FGF-21 levels were decreased (1.60±0.08 vs. 1.30±0.05, P<0.05, Figure 1) concomitant with ameliorations in insulin resistance and β-cell dysfunction, which were shown by a significant decrease in HOMA-IR values and a significant increase in HOMA-IS values (both P<0.01, Table 1).