In summary, we found no compelling evidence for associations between CRC and genetic polymorphisms in VDR. Although we observed a nominally significant CRC association with a SNP that is highly correlated with ApaI in AAs, this association was observed in only one of the two AA study groups; moreover, associations were not detected between CRC and other VDR tagSNPs in AAs. Here, VDR is linked to colorectal carcinoma.