TMV secreted by cancer cells can convert CD4(+)CD25(–) T cells into CD4(+)CD25(+)FOXP3(+) Treg, while increasing the expression by these cells of immune-suppressive factors, such as FasL, IL-10, TGF-β1, CTLA-4, granzyme B, and perforin [60]. The gene discussed is TGFB1; the disease is cancer.