PIK3CD and neoplasm: Moreover, inactive p110δ or p85α/p55α/p50α depletion was shown to result in significantly compromised NKG2D, Ly49D, and NK1.1 receptor-mediated cytokine and chemokine generation in NK cells, even if the NK-mediated cytotoxicity against tumor cells was affected only in mice lacking p85 regulatory subunit [40, 41].