In summary, we have identified five new genes contributing to SLE risk: NCF2, IKZF1, IRF8, IFIH1 and TYK2. Dense fine-mapping and/or genomic re-sequencing of each locus will be required to reveal the functional alleles for each gene with respect to immune dysregulation in lupus. The gene discussed is IRF8; the disease is systemic lupus erythematosus.