SH2B3 and systemic lupus erythematosus: These analyses increased the evidence of association for a number of additional loci that had shown borderline significance in the original US/SWE GWAS (Table 3), including CFB, C12ORF30, SH2B3, and IL12B. Genotyping of additional samples will be required to determine if the association signals shown in Table 3 represent confirmed genetic loci for SLE.