Through Cox regression survival analysis of the variants in HIV-1 natural cohorts, we identified three polymorphisms (CCRL2-Y167F, CCR3-255C and CCR8-27G) as having previously unidentified correlation with AIDS progression that appear to confer additional effect beyond the well-studied AIDS-modifying polymorphisms CCR5-Δ32, CCR5-P1/CCR5-2459A, and CCR2-64I. The gene discussed is CCR2; the disease is AIDS.