Therefore, the best predictive model accounting for the rate of progression to AIDS (1987 CDC definition) includes the newly identified variants CCRL2-167F and -243V, CCR8-27G, as well as previously known variants: the two locus CCR2-V64I-CCR5-Δ32 composite genotype, CCR5-2459, HLA class 1 homozygosity, HLA-B*35Px, HLA-B*57 and HLA B*27 (without covariates, AIC:1796.32, with 9 covariates, AIC:1737.28). The gene discussed is CCR8; the disease is AIDS.