We confirmed the elevated GSIS in high risk mice (Figure 6A) but found no significant difference in glucose responses to intraperitoneal glucose or insulin between the groups (Figures 6B,C), in the Homeostatic model assessment of insulin resistance (HOMA-IR) index or GLUT4 expression in white adipose tissue and muscle (Figure 6D,F). Here, SLC2A4 is linked to Insulin resistance.