In fact this increased GSIS associated to early evolutive stages towards T1D is consistent with our earlier findings indicating that the children who later progress to diabetes are characterized by low serum ketoleucine and elevated levels of the more insulinotropic aminoacid leucine prior to seroconversion to insulin autoantibody (IAA) positivity [2], [17]. The gene discussed is INS; the disease is type 1 diabetes mellitus.