The list of up and downregulated genes in VEGFA165 tumours include known genes involved in neoplasia (e.g. S100A8 involved in leukaemia; S100A9 in prostate carcinoma; BCL9, CCND1 and CTNNB1) (Hermani et al, 2006; Mani et al, 2009; Nicolas et al, 2011; Siapati et al, 2011). Here, S100A8 is linked to neoplasm.