TYR and melanoma: In addition, as melanoma cells are coupling proliferation and differentiation through MITF (Wellbrock et al, 2008), the transcription factor that control the synthesis of TYR, TYRP1 and DCT genes (Murisier and Beermann, 2006), we may reasonably assume that high level of expression of genes involved in melanogenesis results from a net balance of the MITF activity.