Corroborating our results, a previous study reported that the repression of TYRP1 is concomitant to the induction of an isoform of the microtubule-associated protein 2 (MAP-2), a marker of immature neurons (Fang et al, 2001), and that patients with MAP2-positive (hence, low TYRP1) primary melanomas have a significantly improved survival (Soltani et al, 2005). The gene discussed is TYRP1; the disease is melanoma.