In multivariate analysis (Additional file 3, Table S3), the features associated with shorter DFS (Wald test) were age inferior to 50 years (HR = 1.31), more than three involved axillary lymph nodes (HR = 1.94): pathological tumor size superior or equal to 20 mm (HR = 1.78), SBR grade superior to 1 (HR = 1.77 for grade 2, HR = 2.46 for grade 3), and negative hormone receptor status (HR = 1.76), validating the pre-planned choice of these variables as adjustment variables for multivariate analyses. This evidence concerns the gene NR4A1 and neoplasm.